Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate → Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

HRID 1449470노트

반응식

HRID 1449470 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-])=O)[CH:4]=[C:3]1[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)C.[Pt]>[NH2:7][C:5]1[CH:4]=[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:2]([CH3:1])[CH:6]=1

참가 물질

4

반응물 1

HCID 10442704Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

생성물 1

HCID 11182847Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

Ethyl 1-methyl-4-nitro-2-pyrrolecarboxylate (16.0 g, 0.081 mol) (M. J. Weiss, J. S. Webb and J. M. Smith, J. Amer. Chem. Soc., 79, 1266 (1957)) is dissolved in (200 mL) ethanol and (1.60 g) of 10% platinum on carbon is then added. The mixture is shaken for 16 hours in a PARR hydrogenator. The catalyst is removed by filtration through a pad of celite and the filtrate is concentrated in vacuo to a yellow oil. The oil is carried on directly without purification.

후처리

  1. customThe catalyst is removed by filtration through a pad of celite
  2. concentrationthe filtrate is concentrated in vacuo to a yellow oil
  3. customdirectly without purification

출처 및 근거

ORD 기록
ord-fbf56bdb76974a95b817299c907085e2
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599772

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