Chlorosuccinimide → 3,7-Dichloro-5-ethylpyrazolo[1,5-a]pyrimidine

HRID 1450371노트

반응식

HRID 1450371 반응식
[Cl:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=1.[Cl:13]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Cl:13][C:10]1[CH:9]=[N:8][N:7]2[C:2]([Cl:1])=[CH:3][C:4]([CH2:11][CH3:12])=[N:5][C:6]=12

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 105354107-Chloro-5-ethylpyrazolo[1,5-a]pyrimidine

생성물 1

HCID 106324843,7-Dichloro-5-ethylpyrazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

5.5 g (30 mmol) of the chloro compound (Example 1, Step B) and 4.0 g (30 mmol) of N-chlorosuccinimide were dissolved in 150 ml chloroform, stirred for 4 h at room temperature, and finally heated for some minutes on a steam bath. The mixture was poured on to ice water, the aqueous layer extracted with dichloromethane, the combined organic layers washed twice with saturated sodium carbonate solution, dried over sodium sulfate, and evaporated in in vacuo. The title compound was obtained as an oil after chromatography on silica gel with dichloromethane.

후처리

  1. temperaturefinally heated for some minutes on a steam bath
  2. extractionthe aqueous layer extracted with dichloromethane
  3. washthe combined organic layers washed twice with saturated sodium carbonate solution
  4. dry with materialdried over sodium sulfate
  5. customevaporated in in vacuo

출처 및 근거

ORD 기록
ord-7bb056b913c64aea94f5a54215db64f2
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602137

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