3,4-dihydro-2H-pyran → 3-Butyryl-1,2-benzisoxazole

반응식

[C:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)([OH:3])=O.[CH2:13]([CH:15](C(O)=O)C(O)=O)[CH3:14].O1C=CCCC1>>[C:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][N:5]=1)(=[O:3])[CH2:14][CH2:13][CH3:15]

참가 물질

반응물 3

HCID 80803,4-dihydro-2H-pyran

HCID 11756Ethylmalonic acid

HCID 27354451,2-Benzoxazole-3-carboxylic acid

생성물 1

HCID 199769213-Butyryl-1,2-benzisoxazole

실험 절차

Using 3.7 g (23 mmol) of 3-carboxy-l,2-benzisoxazole prepared in accordance with a known process [J. Amer. Chem. Soc., 97, 7305 (1975)], 3.34 g (25 mmol) of ethylmalonic acid and 6.4 g of 3,4-dihydropyran, 3-butyryl-1,2-benzisoxazole was obtained as colorless crystals by similar treatment to Example 28-(4).

출처 및 근거

ORD 기록: ord-ec9997827df944aeb91ad01039947c29
출처 데이터셋: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05602160

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