Sodium Hydroxide → 3-Aminomethylbenzoic acid hydrate

반응식

Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>>[OH2:8].[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 2794825Methyl 3-(aminomethyl)benzoate Hydrochloride

생성물 1

HCID 677173353-Aminomethylbenzoic acid hydrate수율 96.5%

실험 절차

A mixture of methyl 3-aminomethylbenzoate hydrochloride (2.014 g, 0.0098 mol) in 1N sodium hydroxide (25 mL, 0.025 mol) was stirred at room temperature for 4 h. The mixture was neutralized with Dowex-H+ resin. The mixture was filtered and acetone (400 mL) was added to the filtrate. The white precipitate was collected by filtration and recrystallized from water-acetone to give 0.80 g of the title compound as a white powder, mp 278°-280° C.

후처리

filtrationThe mixture was filtered
additionacetone (400 mL) was added to the filtrate
filtrationThe white precipitate was collected by filtration
customrecrystallized from water-acetone

출처 및 근거

ORD 기록: ord-94ff83784eb24d4b963ddcaf7afab86b
출처 데이터셋: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05602277

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