Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethyl Phosphate → Fludarabine Phosphate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethyl Phosphate | HCID 6535 | — |
| 반응물 | Trimethyl Phosphate | HCID 10541 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | Fludarabine | HCID 657237 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Fludarabine Phosphate | HCID 30751 | — |
반응 단계
Phosphorylation: The product from step (e) is mixed with phosphorous oxychloride in an alkyl phosphate such as triethylphosphate, or trimethylphosphate, followed by hydrolysis in water to yield the prodrug 9-β-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate or fludarabine phosphate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05602246 |
| 출처 데이터셋 | uspto-grants-1997_02 |
| ORD ID | ord-3d182ccd67e644cba57efc186652ac7e |
| 출처 메모 | uspto-grants-1997_02 |