HCID 11088367, 화합물 → HCID 19974099, 화합물

HRID 1451359노트

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HRID 1451359 반응식
[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].C[O:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1>Br>[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[OH:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1

참가 물질

3

반응물 1

HCID 11088367HCID 11088367, 화합물

생성물 1

HCID 19974099HCID 19974099, 화합물수율 15%

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

반응 조건

온도
115 °C

실험 절차

A mixture of 9-methoxy-thiazolo[3,2-b]isoquinolinium perchlorate (7 g, 22.19 mmol) in 100 ml of 48% HBr was heated for 18 hours at 115° C. The mixture was concentrated in vacuo, the residue was dissolved in warm water and filtered. The filtrate was treated with sodium perchlorate, the resulting solid was filtered, and washed with water to afford 1.0 g (15%) of 9-hydroxy-thiazolo[3,2-b]isoquinolinium perchlorate (Formula II: A=thiazolo; R1 =H; R6 =9-OH; X- =ClO4-).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionthe residue was dissolved in warm water
  3. filtrationfiltered
  4. additionThe filtrate was treated with sodium perchlorate
  5. filtrationthe resulting solid was filtered
  6. washwashed with water

출처 및 근거

ORD 기록
ord-ef88c70a30c64e83b2f689109e61ec5f
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05604224

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