Hydrogen Bromide → 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone

HRID 1451386

반응식

HRID 1451386 반응식
[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([C:7](=[O:9])[CH3:8])[N:6]=1.[BrH:11].BrBr>C(O)(=O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([C:7](=[O:9])[CH2:8][Br:11])[N:6]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 147385831-(2,5-Dimethyl-1,3-oxazol-4-yl)ethan-1-one

생성물 1

HCID 140762322-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

반응 조건

온도
100 °C

실험 절차

2.8 g (0.02 mol) of 2,5-Dimethyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 35% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 100° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 2 hours the solvent is removed, and the residue is triturated with 50 ml of ether and filtered off with suction.

후처리

  1. customAfter a further 2 hours the solvent is removed
  2. customthe residue is triturated with 50 ml of ether
  3. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-a62a6b22938e4a25a187b70e52d8bddb
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05604225

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