Hydrochloric Acid → 2-Chloro-4-fluorophenylammonium chloride

HRID 1451507노트

반응식

HRID 1451507 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9]C(=O)C.Cl>C(O)C>[Cl-:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH3+:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 5894192'-Chloro-4'-fluoroacetanilide

생성물 1

HCID 199747172-Chloro-4-fluorophenylammonium chloride수율 165.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

A mixture of N-(2-chloro-4-fluorophenyl)acetamide (25.0 g, 133 mmol), concentrated hydrochloric acid (25 ml) and ethanol(50 ml) was heated at reflux for 3 h. The mixture was cooled to 0° C. and left for crystallisation. The precipitate was collected and dried in vacuo to give 20.0 g of 2-chloro-4-fluorophenylammonium chloride.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 3 h
  3. waitleft for crystallisation
  4. customThe precipitate was collected
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-423a61880f524892a77b80463fcdaa6f
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05604242

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