Water → HCID 19972899, 화합물

HRID 1451927노트

반응식

HRID 1451927 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([C:10]3([C:17](=[S:20])[NH:18][CH3:19])[CH2:15][CH2:14][CH2:13][CH2:12][C:11]3=[O:16])=[CH:6][N:5]2[CH:21]=1.[BH4-].[Na+].O>CO>[OH:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][C:10]1([C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:21]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1)[C:17](=[S:20])[NH:18][CH3:19]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 19972896N-Methyl-1-(2-methylimidazo[1,2-a]pyridin-6-yl)-2-oxocyclohexanecarbothioamide

생성물 1

HCID 19972899HCID 19972899, 화합물수율 41%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3.03 g of 1-(2-methylimidazo[1,2-a ]pyridin-6-yl)-N-methyl-2-oxocyclohexanecarbothioamide was suspended in 30 ml of methanol. The obtained suspension was cooled with ice, followed by the addition of 0.15 g of sodium borohydride. The obtained mixture was stirred for one hour, followed by the addition of 50 ml of water. The insoluble matter was recovered by filtration and recrystallized from ethanol and then from acetonitrile to give 1.24 g of the title compound (white powder) as a single diastereomer (yield: 41%).

후처리

  1. temperatureThe obtained suspension was cooled with ice
  2. filtrationThe insoluble matter was recovered by filtration
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-808f26e9213b4a4c8a95d523e0ffc932
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05605907

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