Thionyl Chloride → HCID 19973449, 화합물

HRID 1452043노트

반응식

HRID 1452043 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, 화합물

생성물 1

HCID 19973449HCID 19973449, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

6.80 g of the 2-methylimidazo-[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

후처리

  1. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-d68fb8fe4ccd4e2a87e4aac04f1400b6
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05606061

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