Trimethyl orthoformate → HCID 68822180, 화합물

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[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH3:11])[C:6]=1[S:7]([NH2:10])(=[O:9])=[O:8].[CH:12](OC)(OC)OC>>[CH3:11][C:5]1[C:6]2[S:7](=[O:8])(=[O:9])[N:10]=[CH:12][NH:1][C:2]=2[S:3][CH:4]=1

참가 물질

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HCID 9005Trimethyl orthoformate

HCID 21999992HCID 21999992, 화합물

생성물 1

HCID 68822180HCID 68822180, 화합물

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온도: 90 °C

실험 절차

200 mg of 2-amino-4-methylthiophene-3-sulphonamide, the preparation of which is described in patent WO 99/03861, are dissolved in 1.5 ml of trimethyl orthoformate. The mixture is heated at 90° C. for 2 hours in an open vessel. After evaporation of the solvent under reduced pressure, the residue is taken up in 3 ml of ethyl acetate. The resulting insoluble material is collected by filtration, washed with diethyl ether and dried.

후처리

customAfter evaporation of the solvent under reduced pressure
filtrationThe resulting insoluble material is collected by filtration
washwashed with diethyl ether
customdried

출처 및 근거

ORD 기록: ord-69695625111a4249ada7ca21d0cbfcf6
출처 데이터셋: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07476668B2

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