2,6-Dichloropurine → HCID 178506067, 화합물

HRID 1453605노트

반응식

HRID 1453605 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[C:21]2[C:17]([CH2:18][CH2:19][NH:20]2)=[CH:16][CH:15]=1>C(O)CCC>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:20]2[C:21]3[C:17](=[CH:16][CH:15]=[C:14]([C:13]([F:12])([F:23])[F:24])[CH:22]=3)[CH2:18][CH2:19]2)[N:3]=1

참가 물질

4

반응물 2

HCID 53244122,6-DichloropurineHCID 101764376-(Trifluoromethyl)indoline

생성물 1

HCID 178506067HCID 178506067, 화합물수율 92.4%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

756 mg of 2,6-dichloropurine, 8 ml of butanol and 897 mg of 6-(trifluoromethyl)indoline are mixed and brought to a temperature of 90° C. for approximately 23 hours. The mixture is allowed to return to ambient temperature. Partial drying, washing with ethyl ether and drying under vacuum at 50° C. are carried out, and 1.256 g of expected product are obtained, in the form of beige crystals.

후처리

  1. customto return to ambient temperature
  2. customPartial drying
  3. washwashing with ethyl ether
  4. customdrying under vacuum at 50° C.

출처 및 근거

ORD 기록
ord-7441ed4852aa4a509e750a4802b3e303
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476670B2

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