Sodium Hydroxide → 5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine

HRID 1454871노트

반응식

[F:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH:13]C(=O)C(C)(C)C)=[N:10][C:11]=1[CH3:12].[OH-].[Na+]>>[F:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH2:13])=[N:10][C:11]=1[CH3:12]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 86604238N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide

생성물 1

HCID 862337765-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-ylamine

실험 절차

This material was prepared in analogy to example 86 step B] from N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-2,2-dimethyl-propionamide (0.165 g) and 3M aqueous NaOH (1.23 mL) as an gum (0.174 g) that was used directly in the next step.

출처 및 근거

ORD 기록: ord-980289a6aa99450a8c7ae76245de99f2
출처 데이터셋: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07482341B2

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