3-Aminopyridine → HCID 86608645, 화합물

반응식

[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][C:18]4[N:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=4)[CH:13]=3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1CCC(C(O)=O)CC1.Cl.N[C@H](C(C)C)C(N[C:40]1[CH:41]=[N:42][C:43]([O:46]C2C=C3C(=CC=2)OC(C2C=CC=CC=2)CC3)=[CH:44][CH:45]=1)=O.NC1C=CC(OC2C=C3C(=CC=2)OC(C2C=CC=CC=2)CC3)=NC=1.NC1C=CC=NC=1>>[C:1]1([CH:7]2[CH2:16][CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][C:18]4[N:23]=[CH:22][C:21]([NH:24][C:43]([CH:44]5[CH2:45][CH2:40][CH2:41][NH:42]5)=[O:46])=[CH:20][CH:19]=4)[CH:13]=3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 4

HCID 100093-Aminopyridine

HCID 179784785-Amino-2-(2-phenylchroman-6-yloxy)pyridine

HCID 69015091HCID 69015091, 화합물

HCID 86608644HCID 86608644, 화합물

생성물 1

HCID 86608645HCID 86608645, 화합물

실험 절차

Pyrrolidine-2-carboxylic acid [6-(2-phenylchroman-6-yloxy)pyridin-3-yl]amide and its derivatives were prepared as described for piperidine-4-carboxylic acid [6-(2-phenylchroman-6-yloxy)pyridine-3-yl]amine in Example 19 a) and b) but replacing N-(tert-butoxycarbonyl)isonipecotic acid with (S),(R) or (R,S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester and 5-amino-2-(2-phenylchroman-6-yloxy)-pyridine by an appropriate 5-aminopyridine derivatives.