Methyl iodide → 1-Bromo-2,4-difluoro-3-methoxybenzene
반응식
[OH:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8].[C:11](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:11][O:1][C:2]1[C:3]([F:10])=[C:4]([Br:9])[CH:5]=[CH:6][C:7]=1[F:8]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
A quantity of 3.7 g of 3-hydroxy-2,4-difluoro-bromobenzene is dissolved in 25 ml of acetone and 2.5 g of potassium carbonate is added followed by 2.2 ml of methyl iodide. The mixture is stirred at 20° C. for 6 hours and the solvent evaporated. After addition of dichloromethane, the suspension is filtered. Evaporation of the solvent affords the desired product.
후처리
- customthe solvent evaporated
- additionAfter addition of dichloromethane
- filtrationthe suspension is filtered
- customEvaporation of the solvent
출처 및 근거
- ORD 기록
- ord-b843a672c08d4b78bed914dc9bbe8fc3
- 출처 데이터셋
- uspto-grants-2009_01
- 특허 번호
- US07482454B2
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