Cyclopropylamine → HCID 57535407, 화합물

HRID 1455630노트

반응식

HRID 1455630 반응식
CN(C(ON1N=NC2[CH:12]=[CH:13][CH:14]=[N:15]C1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[Br:25][C:26]1[CH:27]=[C:28]([C:36]([OH:38])=O)[CH:29]=[C:30]2[C:35]=1[N:34]=[CH:33][CH:32]=[CH:31]2.C(N(C(C)C)CC)(C)C.C1(N)CC1>CN(C=O)C.O>[Br:25][C:26]1[CH:27]=[C:28]([C:36]([NH:15][CH:14]2[CH2:12][CH2:13]2)=[O:38])[CH:29]=[C:30]2[C:35]=1[N:34]=[CH:33][CH:32]=[CH:31]2

참가 물질

7

반응물 4

HCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 106584338-Bromo-6-quinolinecarboxylic acid

생성물 1

HCID 57535407HCID 57535407, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A solution of HATU (1.2 eq), 8-bromoquinoline-6-carboxylic acid (1 eq), diisopropylethylamine (2.5 eq) and cyclopropylamine (1.1 eq) was stirred at rt for 1 h in DMF (0.2 M). The reaction mixture was diluted with water, stirred for 2 h and extracted with EtOAc. The organic extracts were washed with brine, dried over MgSO4, filtered and concentrated. The residue was crystallized in EtOAc and title product isolated by filtration as a white powder.

후처리

  1. extractionextracted with EtOAc
  2. washThe organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was crystallized in EtOAc

출처 및 근거

ORD 기록
ord-37ddc407970c45cb86fc405e21f1bc56
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482456B2

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