3,5-Dibromopyridine → 3-Bromo-5-[3-(methylthio)phenyl]pyridine

HRID 1455632노트

반응식

HRID 1455632 반응식
[CH3:1][S:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.[Br:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17](Br)[CH:18]=1>CCOC(C)=O>[Br:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([S:2][CH3:1])[CH:4]=2)[CH:18]=1

참가 물질

4

반응물 2

HCID 693693,5-DibromopyridineHCID 27343833-(Methylthio)benzeneboronic acid

생성물 1

HCID 689546353-Bromo-5-[3-(methylthio)phenyl]pyridine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Prepared according to the procedure Coupling-2 using [3-(methylthio)phenyl]boronic acid and 3,5-dibromopyridine as starting material. Flash chromatography (Hex:EtOAc; 95:5-85:15) afforded the title compound.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-e7ab0e56de72400f83edbab8e009073b
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482456B2

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