Thionyl Chloride → 3-(3-Bromo-4-methoxyphenyl)propanoyl chloride

HRID 1455710노트

반응식

HRID 1455710 반응식
S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:7]=[C:8]([CH2:14][CH2:15][C:16]([OH:18])=O)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]>C(Cl)(Cl)Cl>[Br:5][C:6]1[CH:7]=[C:8]([CH2:14][CH2:15][C:16]([Cl:3])=[O:18])[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid

생성물 1

HCID 866051613-(3-Bromo-4-methoxyphenyl)propanoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 102.4 g (0.86 mol) of thionyl chloride is added to a solution of 51.8 g (0.2 mol) of 3-(3-bromo-4-methoxyphenyl)propanoic acid in 700 ml of chloroform. The mixture is heated at reflux for 4 hours, and the solvent is then evaporated off. 53 g are obtained.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 4 hours
  3. customthe solvent is then evaporated off
  4. custom53 g are obtained

출처 및 근거

ORD 기록
ord-0ee2744e847249628c9e61bc778d8953
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482484B2

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