1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine

반응식

Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]#[C:11][CH3:12])[N:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH:17]=[CH:16][CH2:15][CH2:14]1>>[CH2:9]([O:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:13]2[CH2:14][CH:15]=[CH:16][CH2:17][CH2:18]2)[CH:7]=1)[C:10]#[C:11][CH3:12]

참가 물질

반응물 2

HCID 127501,2,3,6-Tetrahydropyridine

HCID 121376024-(2-Butynyloxy)-6-chloropyrimidine

생성물 1

HCID 578198121-(6-(2-Butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine수율 100.9%

실험 절차

0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.41 g of 1,2,3,6-tetrahydropyridine were mixed and left for 2 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.38 g of 1-(6-(2-butynyloxy)pyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (54)).

출처 및 근거

ORD 기록: ord-d976352f2ebb4c96abede001169aa40a
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732448B2

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