Water → N-(2-Benzoylphenyl)-2-bromoacetamide

HRID 1456633

반응식

HRID 1456633 반응식
[Br:1][CH2:2][C:3](Br)=[O:4].[NH2:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].O>ClCCl>[Br:1][CH2:2][C:3]([NH:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 61147Bromoacetyl bromideHCID 760802-Aminobenzophenone

생성물 1

HCID 84439N-(2-Benzoylphenyl)-2-bromoacetamide수율 97.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-5 °C

실험 절차

A solution of bromoacetyl bromide (100 mL, 1.15 mol, Aldrich) dissolved in dichloromethane (300 mL) was added over 30 min to a solution of 2-aminobenzophenone (197 g, 1.0 mol, Fluka) dissolved in dichloromethane (1.3 L) and water (100) mL) cooled to -10° C. under vigorous mechanical stirring. The resulting mixture was stirred for an additional 1 h at --5° C. and then was allowed to warm to ambient temperature. The layers were separated, and the organic extract was washed with dilute sodium bicarbonate, then was dried over sodium sulfate. Evaporation afforded 309.8 g (95%) of 2-bromoacetamidobenzophenone as off-white crystals.

후처리

  1. temperatureto warm to ambient temperature
  2. customThe layers were separated
  3. extractionthe organic extract
  4. washwas washed with dilute sodium bicarbonate
  5. dry with materialwas dried over sodium sulfate
  6. customEvaporation

출처 및 근거

ORD 기록
ord-e71c6b111918467d8dba1546a08d3400
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843941

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