1,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate → 3,3-Dimethylpiperidin-2-one

HRID 1457220노트

반응식

HRID 1457220 반응식
[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C:3]1=[O:15]>CO.Cl.CCOCC>[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:15]

참가 물질

5

반응물 1

HCID 572676081,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate

생성물 1

HCID 112404853,3-Dimethylpiperidin-2-one

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

The title compound of Step (B) (440 mg, 1.94 mmol) in 4 ml MeOH and 15 ml 1N HCl in Et2O was stirred at room temperature overnight. The solvent was evaporated and dried in vacuo to provide the title compound of this step as a light yellow solid which was relatively pure and was used in the next step without further purification.

후처리

  1. customThe solvent was evaporated
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-c0761b5ec2644a81975de9f8880552eb
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05846990

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