Hydrochloric Acid → Methyl 12-aminododecanoate--hydrogen chloride (1/1)

HRID 1457531

반응식

HRID 1457531 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].[ClH:16].[CH3:17]OC(OC)(C)C>>[ClH:16].[CH3:17][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 6966112-Aminododecanoic Acid

생성물 1

HCID 19372000Methyl 12-aminododecanoate--hydrogen chloride (1/1)수율 90.5%

실험 절차

To the suspension of 12-aminododecanoic acid (2.15 g; 10 mmol) in 2,2-dimethoxypropane (100 ml) was added 36% aqueous HCl (10 ml) and the mixture was treated in an ultrasonic bath until all solid material was dissolved. The mixture was then left to stand overnight, concentrated to dryness, dissolved in 40 ml of methanol and precipitated with approximately 500 ml of dry ether to give 2.4 g of 1 (90.5% yield).

후처리

  1. additionthe mixture was treated in an ultrasonic bath until all solid material
  2. dissolutionwas dissolved
  3. waitThe mixture was then left
  4. concentrationconcentrated to dryness
  5. dissolutiondissolved in 40 ml of methanol
  6. customprecipitated with approximately 500 ml of dry ether

출처 및 근거

ORD 기록
ord-d2eabb1642dc4adaa8ccee71a480e632
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849691

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