Carbon Disulfide → 5-Bromo-2,4-dimethoxyphenol
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[OH:11].C(=S)=S.[Br:15]Br>O>[Br:15][C:6]1[CH:5]=[C:4]([OH:11])[C:3]([O:2][CH3:1])=[CH:8][C:7]=1[O:9][CH3:10]참가 물질
5
실험 절차
To a mixed solution comprising 8.6 g of 2,4-dimethoxyphenol and 80 ml of carbon disulfide (CS2) was added dropwise 2.86 ml of bromine at 10° to 15° C. After stirring the mixture at room temperature for one hour, water was added to the reaction mixture and the reaction mixture was extracted with diethyl ether. The extract was washed and dried, and the solvent was removed under reduced pressure. Hexane was added to the obtained residue and the precipitated crystals were collected by filtration to give 12.0 g of 3-bromo-4,6-dimethoxyphenol (yield: 92%, melting point: 78°-80° C.).
후처리
- extractionthe reaction mixture was extracted with diethyl ether
- washThe extract was washed
- customdried
- customthe solvent was removed under reduced pressure
- additionHexane was added to the obtained residue
- filtrationthe precipitated crystals were collected by filtration
출처 및 근거
- ORD 기록
- ord-019c909aa59c45e6912ff3b83990ce73
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05849732
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