Phosphorus oxychloride → 2-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine

HRID 1457745노트

반응식

HRID 1457745 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:13][C:12](=O)[C:11]([CH3:15])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:18])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([Cl:18])[C:11]([CH3:15])=[CH:10][N:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 187845002-(4'Fluorophenyl)-5-methyl-4-pyrimidinone

생성물 1

HCID 187844962-(4'-Fluorophenyl)-4-chloro-5-methylpyrimidine

실험 절차

A mixture of 2-(4'-fluorophenyl)-5-methyl-4-pyrimidinone (0.79 g, 3.9 mmol) (from example 51) and phosphorous oxychloride (3 mL) is heated to reflux for 1 hour.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 1 hour

출처 및 근거

ORD 기록
ord-255f56b8e15f45c8a2c8f666aac10b23
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849758

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