Methyl iodide → HCID 22101417, 화합물
반응식
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CI.[C:18](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]참가 물질
5
실험 절차
5.8 g of 2-bromo-4-fluoro-5-methylsulphonylbenzoic acid are stirred, at room temperature for 12 h, in 20 ml of DMF together with 3.7 ml of methyl iodide and 8.3 g of potassium carbonate. The reaction mixture is then concentrated and 50 ml of water are added to it. The resulting precipitate is filtered off with suction and dried. Methyl 2-bromo-4-fluoro-5-methylsulphonylbenzoate is obtained, m.p. 126°.
후처리
- concentrationThe reaction mixture is then concentrated
- addition50 ml of water are added to it
- filtrationThe resulting precipitate is filtered off with suction
- customdried
출처 및 근거
- ORD 기록
- ord-e7e81265df5449dca25d05449d7eb82e
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05849796
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