Sodium Hydroxide → 1-(1-Benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylic acid

HRID 1458000노트

반응식

HRID 1458000 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([C:15]2([C:18]([O:20]CC)=[O:19])[CH2:17][CH2:16]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH:13]([C:15]2([C:18]([OH:20])=[O:19])[CH2:17][CH2:16]2)[CH2:14]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 54249419Ethyl 1-(1-benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylate

생성물 1

HCID 542820731-(1-Benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylic acid수율 97%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 2.68 g (8.83 mmol) of ethyl 1-(1-benzyloxycarbonyl-3-azetidinyl)cyclopropanecarboxylate dissolved in 27 ml of ethanol was added 27 ml of 1N sodium hydroxide aqueous solution, followed by overnight stirring at room temperature. After evaporation of the solvent, the resulting residue was mixed with 10% citric acid aqueous solution, extracted with chloroform (50 ml×3) and then dried over anhydrous sodium sulfate. By evaporating the solvent, 2.35 g (97%) of the title compound was obtained.

후처리

  1. customAfter evaporation of the solvent
  2. additionthe resulting residue was mixed with 10% citric acid aqueous solution
  3. extractionextracted with chloroform (50 ml×3)
  4. dry with materialdried over anhydrous sodium sulfate
  5. customBy evaporating the solvent

출처 및 근거

ORD 기록
ord-3b9e912f4f134c10a7cfa9425467bc23
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849757

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