Diphenylacetonitrile → N'-hydroxy-2,2-diphenylethanimidamide

HRID 1458229노트

반응식

HRID 1458229 반응식
[C:1]1([CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+]>C(O)C.O>[C:10]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[N:17][OH:18])[NH2:9])[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 6837DiphenylacetonitrileHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 2913048N'-hydroxy-2,2-diphenylethanimidamide수율 30.5%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

A mixture of diphenylacetonitrile (7.0 g), hydroxylamine hydrochloride (3.03 g), and sodium acetate (6.67 g) in 150 ml of 5:1 ethanol-water was refluxed for 4 h. The mixture was concentrated under reduced pressure. The residue was triturated with water, filtrated, and dried to give the title compound (2.5 g) having the following physical data.

후처리

  1. temperaturewas refluxed for 4 h
  2. concentrationThe mixture was concentrated under reduced pressure
  3. customThe residue was triturated with water
  4. filtrationfiltrated
  5. customdried

출처 및 근거

ORD 기록
ord-04c343c5ad6f429ab5e27aefb55f80b6
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849919

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