Methyl Isocyanate → N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide

HRID 1458560노트

반응식

HRID 1458560 반응식
[CH3:1][N:2]=[C:3]=[O:4].[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH2:28])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2>ClCCl>[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH:28][C:3]([NH:2][CH3:1])=[O:4])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 54554464HCID 54554464, 화합물

생성물 1

HCID 22097020N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide수율 91%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methylisocyanate (8.2 μl, 8.0 mg, 0.14 mmol) was added to a solution of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-aminoethyl)-methanesulphonamide (from Preparation 27, 50 mg, 0.127 mmol) in dichloromethane (2 ml) at room temperature under nitrogen. After 30 minutes the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and concentrated under reduced pressure to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide as a pale yellow foam (52 mg, 91%).

후처리

  1. concentrationAfter 30 minutes the mixture was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-790b989a9e4544fb98a0035504d2b89e
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05852016

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