Hydrochloric Acid → (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethyl-1-methylpyrrolidine, hydrochloride
반응식
C([O:8][C@H:9]1[C@H:13]([O:14]CC2C=CC=CC=2)[CH2:12][N:11]([CH3:22])[C@@H:10]1[CH2:23][O:24]CC1C=CC=CC=1)C1C=CC=CC=1.[ClH:32]>[Pd].C(O)C>[ClH:32].[OH:8][C@H:9]1[C@H:13]([OH:14])[CH2:12][N:11]([CH3:22])[C@@H:10]1[CH2:23][OH:24]참가 물질
5
실험 절차
A mixture of (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethyl-1-methylpyrrolidine (Compound 3) (38 mg, 0.067 mmol), 10% Pd/C (30 mg), 4 N HCl (0.1ml) and 99.9% ethanol (5 ml) was reduced in a Parr apparatus at 40 psi for 20 hours. The mixture was filtered and evaporated in vacuo to give (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethyl-1-methylpyrrolidine, hydrochloride (15 mg, yield 88%) as a yellow oil.
후처리
- filtrationThe mixture was filtered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-1ef4b34650bb4652acb1c87612ab26b9
- 출처 데이터셋
- uspto-grants-1998_12
- 특허 번호
- US05854272
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