1,2-Cyclopentanedicarboxylic acid, (1R,2R)-rel- → cis-tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione

HRID 1459692

반응식

HRID 1459692 반응식
[C@@H:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][CH2:3][C@H:2]1[C:6]([OH:8])=O>C(OC(=O)C)(=O)C>[C@@H:2]12[C:6](=[O:8])[O:11][C:9](=[O:10])[C@@H:1]1[CH2:5][CH2:4][CH2:3]2

참가 물질

3

반응물 1

HCID 7273751,2-Cyclopentanedicarboxylic acid, (1R,2R)-rel-

생성물 1

HCID 10920594cis-tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

반응 조건

온도
165 °C

실험 절차

To the trans-cyclopentane-1,2-dicarboxylic acid (1.16 g, 7.33 mmol) at room temperature, was added Acetic anhydride (10 mL, ex). The reaction mixture was refluxed at about 165° C. for 14 hrs. Workup consisted of concentration in vacuo and co-evaporation with toluene three times. The crude product (1.0 g, ~100%, with a little impurity of Acetic anhydride) was given as a brown oily solid.

후처리

  1. concentrationWorkup consisted of concentration in vacuo and co-evaporation with toluene three times

출처 및 근거

ORD 기록
ord-c6c346c9c0b84a029fcbb366463e072d
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05854277

연결된 노트

불러오는 중…