Water → 4-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

HRID 14602

반응식

HRID 14602 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[C:7]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][S:9][CH:10]=1)=[O:4].C(=O)([O-])[O-].[K+].[K+].[Cl:21][C:22]1[CH:23]=[C:24]([OH:29])[CH:25]=[CH:26][C:27]=1[Cl:28].O>CN(C)C=O>[CH3:14][O:13][C:11]([C:7]1[C:6]([NH:5][C:3](=[O:4])[CH2:2][O:29][C:24]2[CH:25]=[CH:26][C:27]([Cl:28])=[C:22]([Cl:21])[CH:23]=2)=[CH:10][S:9][CH:8]=1)=[O:12]

참가 물질

6

반응물 4

HCID 962WaterHCID 72583,4-DichlorophenolHCID 11430Potassium CarbonateHCID 145100033-Carbomethoxy-4-[(chloroacetyl)amino]thiophene

생성물 1

HCID 686874584-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester수율 70.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

To a solution of methyl 4-(2-chloroacetamido)-3-thiophenecarboxylate ([51486-30-7], 100 mg, 0.428 mmol) in dimethylformamide (1.5 mL) was added potassium carbonate (88.7 mg, 0.642 mmol) and 3,4-dichlorophenol (83.7 mg, 0.514 mmol) and the reaction mixture was stirred at 90° C. overnight. After such time water was added. The precipitate was isolated by filtration, washed with water and dried in vacuo to yield the title compound as a white solid (108.1 mg, 70%).

후처리

  1. customThe precipitate was isolated by filtration
  2. washwashed with water
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-a0fc8b04b02f43088383be8b4a8d9aae
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732452B2

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