Sodium Hydroxide → 4-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid

HRID 14603노트

반응식

HRID 14603 반응식
C[O:2][C:3]([C:5]1[C:9]([NH:10][C:11](=[O:22])[CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)=[CH:8][S:7][CH:6]=1)=[O:4].[OH-].[Na+]>C(O)C>[Cl:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[Cl:20])[O:13][CH2:12][C:11]([NH:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][S:7][CH:8]=1)=[O:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 686874584-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester

생성물 1

HCID 160681574-[2-(3,4-Dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid수율 80.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 4-[2-(3,4-dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (80 mg, 0.222 mmol) in suspension in ethanol was added an aqueous solution of sodium hydroxide (1N, 0.333 mL, 0.333 mmol) and the reaction mixture was stirred at room temperature for 48 hours. After such time the reaction mixture was filtered and the filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL). The precipitate was then isolated by filtration, washed with water and dried in vacuo to yield the title compound as a white solid (62.1 mg, 80%).

후처리

  1. filtrationAfter such time the reaction mixture was filtered
  2. additionthe filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL)
  3. customThe precipitate was then isolated by filtration
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-1a0f7243e5134db39c034da113be3b4c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732452B2

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