2-Methoxyethylamine → N-(2-Methoxyethyl)-2-nitroaniline
반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH3:11][O:12][CH2:13][CH2:14][NH2:15]>C(O)CCC>[CH3:11][O:12][CH2:13][CH2:14][NH:15][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]참가 물질
4
실험 절차
To 28.2g of 2-fluoronitrobenzene in 70ml of n-butanol 30.0g of 2-methoxyethylamine were added and the mixture refluxed overnight to give a dark red solution. After cooling the n-butanol was evaporated off and the product extracted into diethyl ether. The diethyl ether was then washed twice with dilute (aqueous) hydrochloric acid, once with dilute (aqueous) sodium carbonate and once with brine. The ether was then dried using magnesium sulphate and evaporated off to give 35g of 2-(2-methoxyethylamino)nitrobenzene as a red liquid.
후처리
- temperaturethe mixture refluxed overnight
- customto give a dark red solution
- customwas evaporated off
- extractionthe product extracted into diethyl ether
- washThe diethyl ether was then washed twice
- additionwith dilute (aqueous) hydrochloric acid
- additiononce with dilute (aqueous) sodium carbonate
- dry with materialThe ether was then dried
- customevaporated off
출처 및 근거
- ORD 기록
- ord-83356119afc449c09c359af5f5aa06fc
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05071468
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