Pyridine → HCID 15019923, 화합물

HRID 1460416노트

반응식

HRID 1460416 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.N1C=CC=CC=1.[N+](C1C=CC=CC=1)([O-])=O.[C:33](Cl)(=[O:36])[CH:34]=[CH2:35]>O.O1CCCC1>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH:15][C:33](=[O:36])[CH:34]=[CH2:35])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 1049PyridineHCID 7416NitrobenzeneHCID 13140Acryloyl chlorideHCID 1176864-((4-Aminophenyl)sulfonyl)phenol

생성물 1

HCID 15019923HCID 15019923, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-(4'-hydroxyphenylsulfonyl)aniline (23.3 g), pyridine (9.4 g) and nitrobenzene (1 ml) is added to 400 ml of tetrahydrofuran. To the ice-cooled solution, 9.0 g of acrylic acid chloride is added dropwise and stirred for 30 min. The stirred mixture is added to 2,000 ml of water and the precipitating crystal is separated by filtration. The resulting crystal is recrystallized with ethanol to obtain the end compound in an amount of 28.5 g. The structure of this compound is verified by IR, NMR and mass spectra.

후처리

  1. additionis added dropwise
  2. customthe precipitating crystal is separated by filtration
  3. customThe resulting crystal is recrystallized with ethanol
  4. customto obtain the end compound in an amount of 28.5 g

출처 및 근거

ORD 기록
ord-342b39efb741490ab8fb551f708e8e4e
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071738

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