Hydrochloric Acid → (S)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]thiazepine hydrochloride

HRID 1460478노트

반응식

HRID 1460478 반응식
[ClH:1].[CH3:2][O:3][C:4]1[CH:32]=[CH:31][C:7]([CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][S:19][C:18]3[CH:27]=[CH:28][CH:29]=[CH:30][C:17]2=3)=[CH:6][CH:5]=1>CCOCC>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][S:19][C:18]3[CH:27]=[CH:28][CH:29]=[CH:30][C:17]2=3)=[CH:31][CH:32]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 9824029(S)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]thiazepine

생성물 1

HCID 67834802(S)-5,11-Dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]thiazepine hydrochloride수율 43%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Excess saturated ethereal hydrogen chloride solution was added to a solution of (S)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]thiazepine (see Examples 1 and 6) (1.30 g) in ether (20 ml) and the mixture was stirred at room temperature for 16 hours. The resulting precipitate was collected, washed several times with ether, dried and recrystallised from ethyl acetate to give the title compound as colourless crystals, (602 mg, 43%), m.p. 189°-190° C., [α]58925 -30.7° (c=0.57 in ethanol).

후처리

  1. customThe resulting precipitate was collected
  2. washwashed several times with ether
  3. customdried
  4. customrecrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-a5f26e2f2374407f8ce6101c199d214e
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071844

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