Benzyl Chloride → 3H-Imidazo(4,5-b)pyridine, 2-(1-methyl-3-piperidinyl)-3-(phenylmethyl)-

반응식

[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)[CH2:4][CH2:3]1.[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([N:16]1[C:11]2=[N:12][CH:13]=[CH:14][CH:15]=[C:10]2[N:9]=[C:8]1[CH:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 7503Benzyl Chloride

HCID 178480226HCID 178480226, 화합물

생성물 1

HCID 30769523H-Imidazo(4,5-b)pyridine, 2-(1-methyl-3-piperidinyl)-3-(phenylmethyl)-

실험 절차

Operation is carried out similarly to the above description with the difference that 2-(1-methylpiperidin-4-yl)-3H-imidazo-[4,5-b] pyridine is reacted with benzylchloride to obtain 3-benzyl-2-(1-methylpiperidin-4-yl)-3H- imidazo-[4,5-b] pyridine which is isolated as fumarate melting at 205°-207° C. (ethyl alcohol).

출처 및 근거

ORD 기록: ord-aacf95e932a04e75a918dd97b38c0cd5
출처 데이터셋: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05071855

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