Water → HCID 19982193, 화합물

HRID 1460550노트

반응식

HRID 1460550 반응식
BrC1C=CC=C[C:3]=1[C:8]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])[O:12][CH:11]([CH3:13])[CH2:10][O:9]1.[OH:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C(=O)C>[Cl:21][C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[C:8]1([CH2:3][O:22][C:23]2[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=2)[O:12][CH:11]([CH3:13])[CH2:10][O:9]1

참가 물질

6

반응물 4

HCID 962WaterHCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 19982196HCID 19982196, 화합물

생성물 1

HCID 19982193HCID 19982193, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A mixture of 2-(bromophenyl)-2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolane (10 g.), 3-hydroxypyridine (3.8 g.) and potassium carbonate (5.5 g.) in N,N-dimethylacetamide (90 ml.) was refluxed with stirring for 18 hours. After the mixture was allowed to cool, it was poured into water and extracted with toluene. The toluene fraction, thereby obtained, was washed with 5% aqueous sodium hydroxide and evaporated to yield 3-[[2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolan-2-yl]methoxy]pyridine as an oil.

후처리

  1. temperaturewas refluxed
  2. temperatureto cool
  3. extractionextracted with toluene
  4. customThe toluene fraction, thereby obtained
  5. washwas washed with 5% aqueous sodium hydroxide
  6. customevaporated

출처 및 근거

ORD 기록
ord-29004a64b67e4c0bb0bb0f60e67f2084
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071862

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