Sodium hydride → trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[2-oxofuran-4(5H)-yloxy]-2H-1-benzopyran-6-carbonitrile
반응식
[CH2:1]1[C:6](=[O:7])[O:5][CH2:4][C:2]1=[O:3].[OH:8][C@H:9]1[C@H:14](OC2CCC(=O)C=2)[C:13]2[CH:22]=[C:23]([C:26]#[N:27])[CH:24]=[CH:25][C:12]=2[O:11][C:10]1([CH3:29])[CH3:28].[H-].[Na+]>O1CCCC1>[OH:8][C@H:9]1[C@H:14]([O:3][C:2]2[CH2:4][O:5][C:6](=[O:7])[CH:1]=2)[C:13]2[CH:22]=[C:23]([C:26]#[N:27])[CH:24]=[CH:25][C:12]=2[O:11][C:10]1([CH3:29])[CH3:28]참가 물질
5
실험 절차
601 mg of tetronic acid and 1.01 g of the epoxide of example 1 are reacted analogously to example 6 with 180 mg of sodium hydride (80%) and 747 mg of borontrifluoride-diethyletherate in tetrahydrofurane. Usual work up yields white crystalls of the title compound. m.p. 111°-114° C. (dichloromethane/ether)