Ethanol → 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

HRID 1460678

반응식

HRID 1460678 반응식
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[N+:20]([O-:22])=[O:21].C=O.C(O)C>Cl.O>[N+:20]([C:5]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:14][CH2:15]2)=[CH:9][C:4]=1[CH:3]=[O:2])([O-:22])=[O:21]

참가 물질

6

반응물 3

HCID 702EthanolHCID 712FormaldehydeHCID 190868632-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

생성물 1

HCID 190868462-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 962Water용매

실험 절차

0.3 Gram of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal, 5 ml of formalin, 1 ml of ethanol and 2 drops of concentrated hydrochloric acid were refluxed by heating. After the reaction was completed, the solvent was removed by evaporation to obtain the residue, then water was added to the residue. The crystals formed were collected by filtration to yield 0.22 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde.

후처리

  1. temperatureby heating
  2. customthe solvent was removed by evaporation
  3. customto obtain the residue
  4. customThe crystals formed
  5. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-a500e6d154d94be0b110e84b4341736f
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071856

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