Potassium Carbonate → 1-Benzyloctahydropyrrolo[3,4-b]pyrrole
반응식
[CH2:1]([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11](C(OCC)=O)[CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH2:1]([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][NH:11][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
55.6 g (0.2 mol) of ethyl 2-benzyl-2,7-diazabicyclo [3.3.0]octane-7-carboxylate are heated under reflux overnight with 300 ml of concentrated hydrochloric acid. The mixture is then rendered alkaline with potassium carbonate and extracted five times with 100 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
후처리
- extractionextracted five times with 100 ml of chloroform each time
- dry with materialthe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
출처 및 근거
- ORD 기록
- ord-ecc56e2601df45bfba6fa7163b46d8dd
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05071999
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