Dicyclohexylcarbodiimide → HCID 14324483, 화합물
반응식
C1(N=C=NC2CCCCC2)CCCCC1.[Cl:16][CH2:17][C:18]1[C:19](=[O:41])[N:20]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([OH:37])=O)=[CH:31][C:30]=2[N+:38]([O-:40])=[O:39])[O:21][C:22]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[CH2:42]([O:54][CH2:55][CH2:56][CH2:57][NH2:58])[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53]>C(Cl)(Cl)Cl>[Cl:16][CH2:17][C:18]1[C:19](=[O:41])[N:20]([C:29]2[CH:34]=[CH:33][C:32]([C:35](=[O:37])[NH:58][CH2:57][CH2:56][CH2:55][O:54][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53])=[CH:31][C:30]=2[N+:38]([O-:40])=[O:39])[O:21][C:22]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1참가 물질
5
실험 절차
After adding 90.8 g of dicyclohexylcarbodiimide to a mixture of 150 g (0.400) of 4-chloromethyl-5-phenyl-2-(4-carboxy-2-nitrophenyl)-4-isoxazolin-3-one prepared in the above step and 600 ml of chloroform, the reaction was performed for 30 minutes at room temperature. Then, 97.4 g of 3-dodecyloxypropylamine was added dropwise to the reaction mixture and thereafter, the reaction was further performed for 5 hours. The reaction product was purified by a short column of silica gel and the product was recrystallized from acetonitrile to provide 78.0 g of the desired product with a yield of 33.4%. The melting point thereof was 110° C. to 111° C.