Potassium Iodide → Methyl 4-methoxy-2-propoxybenzoate

HRID 1460974

반응식

HRID 1460974 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:13])[C:6](=[CH:11][CH:12]=1)[C:7]([O:9][CH3:10])=[O:8].Br[CH2:15][CH2:16][CH3:17].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([O:13][CH2:15][CH2:16][CH3:17])[CH:4]=1

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 79523Methyl 4-methoxysalicylate

생성물 1

HCID 21250797Methyl 4-methoxy-2-propoxybenzoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A stirred mixture of methyl 4-methoxysalicylate (25 g), bromopropane (15.6 ml), potassium iodide (2.82 g) and anhydrous potassium carbonate (27.53 g) was heated under reflux for 48 hours. The cooled reaction mixture was filtered and the filtrate was evaporated under reduced pressure to yield an oil which was dissolved in diethyl ether (200 ml). The ethereal solution was extracted with aqueous sodium hydroxide to remove unreacted starting material and the organic phase was then washed with water and brine, dried (magnesium sulphate) and evaporated under reduced pressure to yield methyl 4-methoxy-2-propoxybenzoate, 22.45 g.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customThe cooled reaction mixture
  4. filtrationwas filtered
  5. customthe filtrate was evaporated under reduced pressure
  6. customto yield an oil which
  7. extractionThe ethereal solution was extracted with aqueous sodium hydroxide
  8. customto remove unreacted
  9. washthe organic phase was then washed with water and brine
  10. dry with materialdried (magnesium sulphate)
  11. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-bb21f7a10ca3490a95cfe0880b422987
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05073559

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