Hydrochloric Acid → HCID 19981542, 화합물

HRID 1461124노트

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HRID 1461124 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].Cl.[NH:7]([CH2:9][C:10]([NH2:12])=[O:11])[CH3:8].C(=O)(O)[O-].[Na+].Cl>C1C=CC=CC=1.O>[Cl:1][CH2:2][C:3]([N:7]([CH2:9][C:10]([NH2:12])=[O:11])[CH3:8])=[O:4]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 516892Sodium BicarbonateHCID 138929562-(Methylamino)acetamide hydrochloride

생성물 1

HCID 19981542HCID 19981542, 화합물수율 52%

시약·촉매·용매 2

HCID 241Benzene용매HCID 962Water용매

실험 절차

A solution of chloroacetyl chloride (0.1 mole, 11.3 g) in benzene (40 ml) was added over 30 min to a mixture of sarcosinamide hydrochloride (0.1 mole, 12.45 g) and sodium bicarbonate (0.25 mole, 20.0 g) in 40 ml of water. The mixture was vigorously stirred for 3 h at room temperature. The aqueous phase was acidified with 5M hydrochloric acid to pH 5 and extracted with ethyl acetate (3×400 ml). The combined extracts were dried over anhydrous sodium sulphate and evaporated in vacuo. The solid residue obtained was recrystallized from ethanol-ether to give 8.5 g (52%) of the title compound. Mp 85°-86° C.

후처리

  1. extractionextracted with ethyl acetate (3×400 ml)
  2. dry with materialThe combined extracts were dried over anhydrous sodium sulphate
  3. customevaporated in vacuo
  4. customThe solid residue obtained
  5. customwas recrystallized from ethanol-ether

출처 및 근거

ORD 기록
ord-f8173cda14794ab7b9909c6412c37795
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05073641

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