Hydrochloric Acid → 6-(Dimethylamino)-4,4-diphenylheptanoic acid

HRID 1461148노트

반응식

HRID 1461148 반응식
[CH3:1][N:2]([CH3:25])[CH:3]([CH3:24])[CH2:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][CH2:7][C:8]([O:10]C)=[O:9].C(=O)([O-])[O-].[K+].[K+].CO.Cl>O>[CH3:25][N:2]([CH3:1])[CH:3]([CH3:24])[CH2:4][C:5]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 19981498Methyl 6-dimethylamino-4,4-diphenyl-heptanoate

생성물 1

HCID 2194886-(Dimethylamino)-4,4-diphenylheptanoic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of methyl 6-dimethylamino-4,4-diphenyl-heptanoate (obtained above), potassium carbonate (500 mg), methanol (5 ml) and water (1 ml) was stirred at room temperature for 24 hours. The reaction mixture was diluted with water, acidified with 1N HCl to pH 1, and extracted with chloroform (3×). The combined extracts were washed with water and brine (once each). After drying over magnesium sulfate, the solution was rotary evaporated to yield 40 mg of 6-dimethylamino-4,4-diphenyl-heptanoic acid.

후처리

  1. extractionextracted with chloroform (3×)
  2. washThe combined extracts were washed with water and brine (once each)
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solution was rotary evaporated

출처 및 근거

ORD 기록
ord-5c2dd9e0e8e5416e9c0fdbd760508a75
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05073629

반응 노트

불러오는 중…