Hydroxyamine hydrochloride → HCID 86744460, 화합물

HRID 1461428노트

반응식

HRID 1461428 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[CH:12]=O.Cl.[NH2:19][OH:20]>N1C=CC=CC=1>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[CH:12]=[N:19][OH:20]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 15027376HCID 15027376, 화합물

생성물 1

HCID 86744460HCID 86744460, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 2-[(2,3-dimethylphenyl)amino]benzaldehyde (11 g, 0.049 mol) and hydroxylamine hydrochloride (17 g, 0.25 mol) in pyridine (250 ml) is stirred at room temperature overnight. The solvent is evaporated and the residue is partitioned between ethyl acetate (200 ml) and 10% aqueous HCl (200 ml). The organic layer is washed with 10% aqueous HCl (200 ml) and water (2×100 ml). The organic layer is dried (MgSO4) and the solvent is evaporated to give 2-[(2,3-dimethylphenyl) amino]benzaldehyde oxime which is recrystallized from hexane. Yield 7.3 g (62%); mp 107°-108° C.

후처리

  1. customThe solvent is evaporated
  2. customthe residue is partitioned between ethyl acetate (200 ml) and 10% aqueous HCl (200 ml)
  3. washThe organic layer is washed with 10% aqueous HCl (200 ml) and water (2×100 ml)
  4. dry with materialThe organic layer is dried (MgSO4)
  5. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-a268f8f519ef464db6e6acca06f0bf16
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05075330

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