1(2H)-Phthalazinone → HCID 19979310, 화합물

HRID 1461746노트

반응식

HRID 1461746 반응식
[OH-].[K+].[O:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][NH:5]1.Br[CH2:15][CH2:16][O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1>O.CS(C)=O>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[O:17][CH2:16][CH2:15][N:5]1[N:6]=[CH:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:3]

참가 물질

6

반응물 3

HCID 83941(2H)-PhthalazinoneHCID 14797Potassium HydroxideHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyran

생성물 1

HCID 19979310HCID 19979310, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated.

후처리

  1. customobtained
  2. waitThe mixture is left
  3. concentrationconcentrated
  4. extractionthe product is extracted with dichloromethane
  5. concentrationThe organic phase is concentrated

출처 및 근거

ORD 기록
ord-725db703735c4a669a505d486e532aa0
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05077288

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