Sodium Hydroxide → [3-[2-(4,5-Diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid

HRID 1461756노트

반응식

HRID 1461756 반응식
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:29]=[CH:30][CH:31]=3)[O:23][CH2:24][C:25]([O:27]C)=[O:26])[S:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][C:20]3[CH:21]=[C:22]([CH:29]=[CH:30][CH:31]=3)[O:23][CH2:24][C:25]([OH:27])=[O:26])[S:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10477744Methyl [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl]phenoxy]acetate

생성물 1

HCID 15006905[3-[2-(4,5-Diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid수율 79%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl]phenoxy]acetate (2.70 g, 6mmol), 5N NaOH solution (3.77mL, 18mmol) and methanol (40 mL) was heated to reflux on a steam bath. After 20 minutes, the mixture was cooled, the methanol removed and the residue diluted with water and 2N HCl solution. The precipitate was filtered off, washed with water and dried in air. Recrystallization from a mixture of CH2Cl2 and hexanes provide [3-[2-(4,5-diphenyl-2-thiazolyl)ethyl)phenoxy]acetic acid (1.97 g, 75%), mp 118°-120° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux on a steam bath
  3. temperaturethe mixture was cooled
  4. customthe methanol removed
  5. additionthe residue diluted with water and 2N HCl solution
  6. filtrationThe precipitate was filtered off
  7. washwashed with water
  8. customdried in air
  9. customRecrystallization
  10. additionfrom a mixture of CH2Cl2 and hexanes

출처 및 근거

ORD 기록
ord-b2f6f0cd736649ea822c3377408cd6ad
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05077305

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