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2-Ethylhexanol → HCID 54546381, 화합물

HRID 1461888
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HRID 1461888 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH:8]=[CH:9][C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[CH2:18]([CH:20]([CH2:23][CH2:24][CH2:25][CH3:26])CO)[CH3:19]>C([Sn](=O)CCCC)CCC.C1(C)C=CC=CC=1>[C:1]([C:5]1[CH:6]=[C:7]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH:20]([CH2:18][CH3:19])[CH2:23][CH2:24][CH2:25][CH3:26])=[O:15])[CH:8]=[CH:9][C:10]=1[OH:11])([CH3:4])([CH3:2])[CH3:3]
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참가 물질

5

반응물 2

HCID 77202-EthylhexanolHCID 3084638Benzenepropanoic acid, 3-(1,1-dimethylethyl)-4-hydroxy-, methyl ester

생성물 1

HCID 54546381HCID 54546381, 화합물수율 94.6%

시약·촉매·용매 2

HCID 61221Dibutyltin oxide촉매HCID 1140Toluene용매2회

반응 조건

온도
140 °C

실험 절차

A mixture of 45 g of methyl 3-(3-tert-butyl-4-hydroxyphenyl)propionate, 24.7 g of 2-ethylhexylalcohol, 0.5 g of dibutyltin oxide and 50 ml of toluene was heated to 140° C., whereto toluene was further added while the solvent was being distilled off. After the mixture was stirred for 10 hours, toluene was distilled off. The obtained residue was purified by silica gel column chromatography to give 60 g of 2-ethylhexyl 3-(3-tert-butyl-4-hydroxyphenyl)propionate as a pale yellow oily substance.

후처리

  1. distillationwas being distilled off
  2. distillationtoluene was distilled off
  3. customThe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e0873a5df8554f218e40c9abdce6c4c7
출처 데이터셋
uspto-grants-1991_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05077424

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