2H-1,2,4-Oxadiazin-3(4H)-one, dihydro-5-thioxo- → HCID 178442899, 화합물

HRID 1462197노트

반응식

HRID 1462197 반응식
[O:1]1[CH2:6][C:5](=S)[NH:4][C:3](=[O:8])[NH:2]1.[CH2:9]([NH2:27])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]\[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:9]([NH:27][C:5]1[CH2:6][O:1][NH:2][C:3](=[O:8])[N:4]=1)[CH2:10][CH2:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

3

반응물 2

HCID 30069082H-1,2,4-Oxadiazin-3(4H)-one, dihydro-5-thioxo-HCID 5356789Oleylamine

생성물 1

HCID 178442899HCID 178442899, 화합물수율 16.4%

실험 절차

To 0.66 g (0.005 mole) of 6H-1,2,4-oxadiazin-3(2H)-one-5(4H)-thione dissolved in 10 ml of freshly distilled dry dioxane is added 1.33 g (0.0051 mole) of oleylamine. The reaction mixture is stirred for 17 hours at room temperature and the crystalline material filtered, washed with additional dry dioxane and chloroform, and dried to give 0.3 g (16 percent) of 5-(4-octadecenylamino)-6H-1,2,4-oxadiazin-3(2H)-one.

후처리

  1. distillationof freshly distilled dry dioxane
  2. filtrationthe crystalline material filtered
  3. washwashed with additional dry dioxane and chloroform
  4. customdried

출처 및 근거

ORD 기록
ord-f780cc7bcec741a1980ac2d72229e5d4
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04459403

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