Benzoyl chloride → alpha-N-benzoylamino-2-acetylthiophene

HRID 1462419노트

반응식

HRID 1462419 반응식
Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([NH:10][CH2:9][C:7]([C:3]1[S:2][CH:6]=[CH:5][CH:4]=1)=[O:8])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 3

HCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 126098332-Amino-1-(thiophen-2-yl)ethan-1-one hydrochloride

생성물 1

HCID 13105421alpha-N-benzoylamino-2-acetylthiophene수율 94%

실험 절차

5 g of N-[(2-thienylcarbonyl)methyl]amine hydrochloride, 10 g of sodium bicarbonate and 3.9 g of benzoyl chloride are treated in the same manner as described in Preparation 1-(3). 6.4 g of N-benzoyl-N-[(2-thienylcarbonyl)methyl]amine are thereby obtained. Yield: 93.3%

후처리

  1. customas described in Preparation 1-(3)

출처 및 근거

ORD 기록
ord-faf90c3ce25044c7bb039e1ab8eafe3e
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04460596

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